Download Von Willebrand Disease: Basic and Clinical Aspects by Augusto B. Federici, Christine A. Lee, Erik E. Berntorp, PDF

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By Augusto B. Federici, Christine A. Lee, Erik E. Berntorp, David Lillicrap, Robert R. Montgomery

Von Willebrand illness: easy and medical Aspects presents an perception into all points of the situation. in view that its discovery, von Willebrand ailment has been commonly studied and the causative issue deficiency, the knowledge of the and its remedy has drastically more desirable. This booklet summarizes fresh study and may support to optimize the administration of sufferers with von Willebrand illness.

This precious e-book describes the real and complicated function of von Willebrand think about hemostasis and thrombosis. as well as the present figuring out of its molecular biology, this e-book offers specific concentration to the organization among genetic editions of von Willebrand issue and varied von Willebrand disorder phenotypes. It additionally reports the $64000 quarter of the obstetric and gynecological manifestations of von Willebrand affliction, in addition to the remedy of acute bleeding.

Written through a world staff of individuals it describes the development in, and problems of diagnosing phenotypes and genotypes. Molecular analysis of sort 1, variety 2 and its subgroups, and sort three von Willebrand illness are provided in addition to dialogue of the aptitude destiny position of gene therapy.

Von Willebrand sickness: simple and medical Aspects is a helpful source for hematologists in perform and in education, and experts in thrombosis and hemostasis.

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Extra resources for Von Willebrand Disease: Basic and Clinical Aspects

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192 Vischer UM, Wagner DD. CD63 is a component of Weibel–Palade bodies of human endothelial cells. Blood 1993; 82: 1184–91. 193 Wolff B, Burns AR, Middleton J, Rot A. Endothelial cell ‘memory’ of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel– Palade bodies. J Exp Med 1998; 188: 1757–62. 194 Shahbazi S, Lenting PJ, Fribourg C, et al. Characterization of the interaction between von Willebrand factor and osteoprotegerin. J Thromb Haemost 2007; 5: 1956–62. 195 Schnyder-Candrian S, Borsig L, Moser R, Berger EG.

EMBO J 1986; 5: 1839– 47, erratum in EMBO J 1986; 5: 3074. BIOSYNTHESIS AND ORGANIZATION OF VWD 22 Hannah MJ, Skehel P, Erent M, et al. Differential kinetics of cell surface loss of von Willebrand factor and its propolypeptide after secretion from Weibel–Palade bodies in living human endothelial cells. J Biol Chem 2005; 280: 22827–30. 23 McCarroll DR, Ruggeri ZM, Montgomery RR. The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand’s disease.

EMBO J 1986; 5: 1839– 47, erratum in EMBO J 1986; 5: 3074. BIOSYNTHESIS AND ORGANIZATION OF VWD 22 Hannah MJ, Skehel P, Erent M, et al. Differential kinetics of cell surface loss of von Willebrand factor and its propolypeptide after secretion from Weibel–Palade bodies in living human endothelial cells. J Biol Chem 2005; 280: 22827–30. 23 McCarroll DR, Ruggeri ZM, Montgomery RR. The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand’s disease.

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