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Thrombopoielin (TPO) is the most important regulator of platelet construction and is produced constilulively through the hepatocyte. it really is secreted into the movement the place it's in most cases certain and got rid of through thrombopoielin receptors (c-mpl) on platelets and megakaryocytes. the rest thrombopoielin within the stream regulates the expansion of bone marrow megakaryocytes and the creation of platelets. With a decline in platelet construction the circulating focus of thrombopoietin rises. The human thrombopoielin glycoprotein comprises an erythropoietin-like area (residues 1-153) that's 50% just like erythropoietin and a carbohydrate-rich area (residues 154-332) that's hugely glycosylated and looks to be beneficial for secretion and balance of the mature protein.

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McBride, S. , Trouton, T. , and Wilson, C. (2002) Randomized comparison of enoxaparin with unfractionated heparin following fibrinolytic therapy for acute myocardial infarction. Eur. Heart J. 23, 627–632. 35. Direct Thrombin Inhibitor Collaboration Investigators (2002) Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patient’s data. Lancet 359, 294–302. CH03,21-34,14pgs 9/5/03 11:01 AM Page 21 3 Evaluation of Platelet Antagonists in In Vitro Flow Models of Thrombosis Owen J.

2. Allow platelets to bind to APES-treated cover slip in a humid environment at 37°C for 30 min. CH03,21-34,14pgs 9/5/03 11:01 AM Page 30 30 McCarty et al. 3. Monocytic THP-1 Cell-Platelet Adhesion Assay 1. Assemble the platelet-coated cover slip on a parallel-plate flow chamber that is then mounted on the stage of an inverted microscope equipped with a CCD camera connected to a VCR and TV monitor. 2. Perfuse the antiplatelet antagonist at the desirable concentration or vehicle (control) over surface-bound platelets, and incubate for 10 min.

19. Abulencia, J. , McCarty, O. J. , Mousa, S. , and Konstantopoulos, K. (2001) Comparative antiplatelet efficacy of a novel, nonpep- CH03,21-34,14pgs 34 20. 21. 22. 23. 24. 9/5/03 11:01 AM Page 34 McCarty et al. tide GPIIb/IIIa antagonist (XV454) and Abciximab (c7E3) in Flow Models of Thrombosis. Arterioscler. Thromb. Vasc. Biol. 21, 149–156. Turner, N. , Moake, J. , Kamat, S. , Schafer, A. , Kleiman, N. , and McIntire, L. V. (1995) Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb-IIIa.

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