Download Textbook of Hemophilia by Christine A. Lee, Erik E. Berntorp, W. Keith Hoots, Louis M. PDF

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By Christine A. Lee, Erik E. Berntorp, W. Keith Hoots, Louis M. Aledort MD

The one up to date definitive reference resource on hemophiliaThis ebook is a useful source that offers an summary of all features of the care of sufferers with haemophilia. masking the best way to verify either bleeding childrens and adults, Haemophilia A and B, molecular foundation of the sickness, the function of things in coagulation, epidemiology, pharmacokinetics, and therapy of inhibitors. there'll even be a piece on musculoskeletal points of haemophilia in addition to more moderen advancements equivalent to gene treatment and infrequent bleeding disorders.Textbook of Hemophilia is perfect for:Trainees and citizens in hematology Hematologists in perform experts operating in thrombosis and hemostasis in addition to transfusion medicineWhy purchase This Book?The in simple terms updated definitive reference resource on hemophiliaEssential for all these dealing with hemophilia sufferers unique suggestions on evaluate, prognosis, administration and therapy suggestion for daily scientific questions Edited via 3 of the world’s prime specialists on hemophilia

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Structure of human factor VIII. Nature 1984; 312: 337–42. 7 Kane WH, Davie EW. Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin. Proc Natl Acad Sci USA 1986; 83: 6800–4. 8 Stubbs JD, Lekutis C, Singer KL, et al. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc Natl Acad Sci USA 1990; 87: 8417–21. 9 Johnson JD, Edman JC, Rutter WJ.

3-fold). Interaction of FVIII with LRP involves multiple (at least three) FVIII binding sites: within the A2 domain of HCh [34] and within the C2 and A3 domains of LCh [33,37]. The A2 domain LRPbinding site has been mapped to the region 484–509 [34]. One LRP-interactive region within LCh has been ascribed to the C2 domain, based on the observation that an anti-C2 domain MAb ESH4 inhibited a high-affinity binding of the FVIII LCh to LRP. The C2 site likely overlaps with the site responsible for FVIII binding to VWF, since the same antibody inhibited FVIII binding to VWF [33].

Am J Haematol 1992; 39: 146–7. 19 Fiorin F, Steffan A, Pradella P, et al. IgG platelet antibodies in EDTA dependent pseudothrombocytopenia bind to platelet membrane glycoprotein Ib. Am J Clin Pathol 1998; 110: 178–83. 20 Quick AJ . Quick on Quick’s test. N Engl J Med 1973; 288: 1079. 21 Laffan MA, Manning RA. Investigation of haemostasis. In: Lewis SM, Bain B, Bates I, eds. Practical Haematology, 9th edn. London: Churchill Livingstone 2001: 339–91. 22 Roberts HR, Stinchcombe T, Gabriel DA. The dysfibrinoginaemias.

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