Download Platelets in Hematologic and Cardiovascular Disorders: A by Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. PDF

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By Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. Page, Jos Vermylen

A fast elevate in our realizing of the biology of platelets and their function in affliction lately has been paralleled via expanding successes with demonstrated platelet-modifying remedies in lots of medical stipulations. this article makes a speciality of the medical position of platelets in a wide selection of hematologic, cardiovascular and different problems, delivering a pragmatic, clinically proper guide for all clinicians and researchers drawn to platelets and their position in disorder. masking platelet body structure, bleeding problems, thrombotic issues and antithrombotic remedy. Chapters disguise the entire traditional and no more traditional facets of platelet involvement in disorder, with an emphasis on contemporary medical advancements. transparent take domestic messages were integrated in each one bankruptcy to assist scientific perform. With contributions from best specialists throughout 3 continents, Platelets in Hematologic and Cardiovascular issues is an up to date, good illustrated, sensible source for everybody considering scientific perform with platelet problems.

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Extra resources for Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook

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Zucker-Franklin D, Benson K, Myers K. Absence of a surface-connected canalicular system in bovine platelets. Blood 1985;65:241–4. 85. Shaklai M, Tavassoli M. Demarcation membrane system in rat megakaryocyte and the mechanism of platelet formation: A membrane reorganization process. J Ultrastruct Res 1978;62:270–85. 86. Kosaki G. In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets? Int J Hematol 2005;81:208–19. 87. Radley J, Hatshorm M. Megakaryocyte fragments and the microtubule coil.

153. Yin HL, Stossel TP. Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature 1979;281:583–6. 154. Fox JE, Phillips DR. Inhibition of actin polymerization in blood platelets by cytochalasins. Nature 1981;292:650–2. CHAPTER 2 PLATELET IMMUNOLOGY: STRUCTURE , FUNCTIONS, AND POLYMORPHISMS OF MEMBRANE GLYCOPROTEINS Yasuo Ikeda, Yumiko Matsubara, and Tetsuji Kamata Keio University School of Medicine, Tokyo, Japan INTRODUCTION The main function of platelets is to arrest bleeding by forming a hemostatic plug through their interaction with damaged vascular wall.

Am J Anat 1976;145:1046–52. 90. Wright J. The origin and nature of blood platelets. Boston Med Surg J 1906;154:643–5. 91. Thiery JB, Bessis M. Platelet genesis from megakaryocytes observed in live cells. C R. Acad Sci Paris 1956;242:290. 92. Behnke O. An electron microscope study of the rat megakaryocyte. II. Some aspects of platelet release and microtubules. J Ultrastruct Res 1969;26:111–29. 93. Choi ES, Nichol JL, Hokom MM, Homkohl AC, Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.

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