Download Myb Transcription Factors: Their Role in Growth, by Jon Frampton PDF

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By Jon Frampton

This quantity represents the 1st selection of articles contributed through examine leaders engaged on the Myb kinfolk of transcriptional regulatory proteins. in additional than twenty chapters the authors talk about the diversity of organic techniques and numerous cellphone forms within which Myb proteins function. even though focusing on the 3 vertebrate Myb family, homologues from reduce species also are mentioned end result of the gentle they can shed at the evolution and serve as of those proteins. person chapters describe the involvement of Myb proteins, particularly c-Myb, in general and diseased improvement and serve as of many tissues together with haemopoietic cells, blood vessels, the gastrointestinal tract and the mind. numerous chapters discover the mechanistic info of the motion of Myb proteins, particularly structural beneficial properties, their interplay with DNA and different regulatory proteins, and the range of genes which are regulatory ambitions for this workforce of transcription elements. This paintings could be of curiosity to these operating at once within the box and in addition to the broader examine neighborhood investigating the transcriptional law of improvement, differentiation and progress. The healing power of manipulating Myb functionality is additionally mentioned making the ebook attractive to clinician scientists in numerous fields together with haematology, oncology and cardiology.

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And Ferrari, S. (1999) Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. Eur. J. Biochem. 260, 384-391. S. R. (2002) Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420, 833-837. , Elias, P. and de Lange, T. (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 16, 1785-1794. , Markus, J. and Wolff, L. (2002) Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity.

L. S. (1996) FAETL motif required for leukemic transformation by vMyb. J. Virol. 70, 5600-5610. , Ramsay, G. L. (2002) Mutations in Drosophila myb lead to centrosome amplification and genomic instability. Development 129, 347-359. A. and Kohler, N. (1999) Discovery of tetraploidy in a mammal. Nature 401, 341. Ganter, B. S. (1999) Myb and oncogenesis. Adv Cancer Res 76, 21-60. Garcia-Fernandez, J. W. (1994) Archetypal organization of the amphioxus Hox gene cluster. Nature 370, 563-566. , Sims, R.

Conservation of phosphorylation sites across all animal 3R Myb proteins suggests a possible common regulation of 3R Myb proteins by MAP kinases through modulation of the conserved negative regulatory domain. , 1999). The second nuclear localisation signal is well conserved in all AMyb, B-Myb and invertebrate Myb sequences investigated with limited conservation in vertebrate c-Myb sequences (Figure 1, NLS2). The DNAbinding regulatory domain identified in Xenopus B-Myb spans a highly conserved phosphorylation motif consisting of three amino acids: theroine/serine, proline and aliphatic amino acids (valine, isoleucine or leucine) (Figure 1, DBRD).

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