Download Molecular Testing in Cancer by George M. Yousef, Serge Jothy PDF

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By George M. Yousef, Serge Jothy

Molecular trying out in Cancer offers a cutting-edge evaluate of clinically suitable molecular pathology in melanoma. The publication presents a short, effortless to learn evaluation of in general hired diagnostic molecular concepts together with lately built "next iteration" analytic instruments, and provides a system-based run-through of the application of molecular trying out in person melanoma kinds, in addition to reviewing present markers in melanoma analysis, analysis, and administration. the quantity additionally offers a potential for the longer term inclusive of lately characterised and rising biomarkers.

Written by way of specialists within the box, Molecular trying out in Cancer serves as an invaluable and finished source for pathologists, hematologists, laboratory technicians and molecular scientists.

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FISH methods utilize locusspecific probes to identify deletions, duplications, and translocations of specific DNA segments [13]. 1). M. Yousef and S. 1007/978-1-4899-8050-2_3, © Springer Science+Business Media New York 2014 27 R. Hubaux et al. 28 Fig. 1 Chromosomal rearrangements. Normal diploid chromosome with a 2n DNA dosage. An abnormal number of chromosomes (chromosomal aneuploidy) or segments (segmental aneuploidy) are common events in tumorigenesis and have a significant impact on patient prognosis.

J Clin Pathol. 2010;63:210–9. Mansfield AS, Sukov WR, Eckel-Passow JE, Sakai Y, Walsh FJ, Lonzo M, et al. Comparison of fluorescence in situ hybridization (FISH) and dual-ISH (DISH) in the determination of HER2 status in breast cancer. Am J Clin Pathol. 2013;139:144–50. Sokolova IA, Halling KC, Jenkins RB, Burkhardt HM, Meyer RG, Seelig SA, et al. The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine. J Mol Diagn.

20. 21. 22. 23. 24. 25. 26. translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982;300:765–7. Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered with a limited region, bcr, on chromosome 22. Cell. 1984;36:93–9. Heisterkamp N, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, et al. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.

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