By Jean Berthier
The applying of microfluidics to biotechnology is an exhilarating new region that has already started to revolutionize how researchers learn and control macromolecules like DNA, proteins and cells in vitro and inside residing organisms. Now in a newly revised and extended moment version, the Artech apartment bestseller, "Microfluidics for Biotechnology" brings execs and scholars to the innovative of this burgeoning box. that includes a variety of updates and together with 3 fullyyt new chapters, this booklet presents an in depth examine the mechanical habit of the different sorts of micro/nano debris and macromolecules which are utilized in biotechnology. Engineers and laboratory researchers concerned with the perception and layout of bio-tech microdevices, in addition to graduate and post-graduate scholars in comparable classes.
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Extra info for Microfluidics for Biotechnology, Second Edition
2! 21) Because the Taylor expansion has been limited to the second order, Huggins law applies for very dilute solutions only. 20) should be kept. 22) where a is a coefficient. 1, [η] of the order of 3–7 L/g and n of the order of 3–4 depending on the type of alginate [9, 10]. 11 Specific viscosity of alginate solution versus concentration: the dots correspond to the experimental values, the curve to the power law (alginate Keltone HV 1%). 8) and fitting with a straight line. 11). 4 Viscosity Variation with Temperature As a general rule, the viscosity of a polymeric liquid decreases with temperature.
Two immiscible liquids are moving in parallel, separated by pillars aligned in the middle. Micro- and nanoparticles or macromolecules carried by one of the liquid migrate through the interface into the other liquid. If the flow rate of this last liquid is small, the particles are automatically concentrated. (Photo courtesy of N. ) For example, alternate plugs of liquid separated by air bubbles are used to create microemulsions or sprays. 3). It is still a multiphase flow, but the discontinuous phase is more or less dispersed in the continuous phase.
To design in order to have the expected flow rate in each branch). Usually such networks are designed considering Newtonian fluids. It is emphasized here that such networks will not work properly for non-Newtonian fluids. 17 shows the change of flow rates in a network depending on the visco-elastic character of the fluid. Using driving pressure conditions at the inlet, the computation shows that the flow rate in the small “branches” is reduced in the non-Newtonian case. 3 Laminarity of Microflows Regardless of the size—macroscopic or microscopic—a fluid flow is said to be laminar when viscous forces dominate inertia.