Download Medication-Related Osteonecrosis of the Jaws: by Sven Otto PDF

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By Sven Otto

Osteonecrosis of the jaws is a widely known side-effect of antiresorptive remedy that predominantly happens in sufferers being affected by malignant ailments and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. much less often it may possibly even be saw in sufferers with osteoporosis who're being taken care of with those antiresorptive medications

This textbook offers particular, up to date details on all points of medication-related osteonecrosis of the jaws, together with medical gains, pathogenesis, remedies, and preventive measures. It additionally explains secure prevention and therapy ideas for sufferers receiving antiresorptive medicines who require extractions, implant insertions, and different dento-alveolar surgical procedures. This ebook could be of significant curiosity for clinical and dental scholars, dentists, and oral and maxillofacial surgeons in addition to osteologists and oncologists.

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Extra resources for Medication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents

Example text

2011;25(1):24–39. 15. Torregrosa JV, Ramos AM. Use of bisphosphonates in chronic kidney disease. Nefrologia. 2010;30(3):288–96. 16. Huang WH, et al. Use of alendronate sodium (fosamax) to ameliorate osteoporosis in renal transplant patients: a case–control study. PLoS One. 2012;7(11): e48481. 17. Abediazar S, Nakhjavani MR. Effect of alendronate on early bone loss of renal transplant recipients. Transplant Proc. 2011;43(2):565–7. 18. Torregrosa JV, et al. Open-label trial: effect of weekly risedronate immediately after transplantation in kidney recipients.

According to the American Association of Oral and Maxillofacial Surgeons (AAOMS) position paper [2], oral BRONJ risk increases when the duration of intake exceeds 3 years. However, there was no supporting scientific evidence for this notion. 2–103 months) for intravenous bisphosphonate intake. Fleisher et al. [62] reported a median 3 years for intravenous bisphosphonates and 5 years for oral bisphosphonates before the onset of ONJ. 8 months [61]. Barasch et al. [54] reported that BRONJ risk begins within 2 years of bisphosphonate administration for both cancer and osteoporosis patients.

Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62(5):527–34. Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol. 2005;23(34): 8580–7. Mavrokokki T, Cheng A, Stein B, Goss A. Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia.

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