Download Experimental Hematology Today—1988: Selected Papers from the by C. L. Epstein (auth.), S. J. Baum, K. A. Dicke, E. Lotzová, PDF

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By C. L. Epstein (auth.), S. J. Baum, K. A. Dicke, E. Lotzová, D. H. Pluznik (eds.)

Experimental Hematology at the present time - 1988 offers the most recent result of study reflecting the various pursuits of uncomplicated and scientific hematologists. the key components explored are hematopoietic law by way of cytokines; hematopoietic mobile progress rules, with emphasis at the interplay of stromal with hematopoietic stem and progenitor cells; granulopoietic regulators; gene transfers into hematopoietic progenitor cells; leukemogenesis; and bone marrow transplantation. All chapters document on study or medical findings of the earlier year.

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Additional resources for Experimental Hematology Today—1988: Selected Papers from the 17th Annual Meeting of the International Society for Experimental Hematology August 21–25, 1988, Houston, Texas, USA

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3, top left). 1 cell line was shown to be capable of supporting the continuous proliferation or myeloid progenitor cells and pre-B lymphocytes In long-term bone marrow cocultures [6, 1, s, 12, 14). We examined the appearance or cobblestone-like areas and evaluated the incidence of GM-CFC and pre-B lymphocytes in these cultures. Myeloid progenitor cells could be recovered from bone marrow cocultures supplemented with HS up to 6 weeks in culture. The mature cell types accumulating in the suspension were mostly myeloid cells at various stages of differentiation.

Although these cell lines have significantly simplified the model systems used for the study of hemopoiesis in vitro, the cultures are very complex and are hard to use when one is trying to evaluate the molecular basis of the mechanisms that control the process. Extracellular matrix components were proposed to be involved in the regulation of hemopoiesis. It was found that stromal cells deposit high amounts of extracellular matrix components, some of which were detected at attachment sites between marrow derived adherent cells and developing granulocytes and macrophages [10, 11].

Salt extraction has been shown to facilitate the binding of GM-CSF to the ECM in marrow stromal cultures, presumably by removing an endogenous growth factor from the matrix [2]. Salt extraction also improved the binding of rh and rgiL-3 from barely detectable levels to 50% of the total activity (cf. Figs 2 and 3). In agreement with the results of Roberts and colleagues [9], our findings suggest that IL-3 can bind to heparan sulphate in the extracellular matrix of the marrow microenvironment. We have demonstrated that GM-CSF binds to glycosaminoglycans in the ECM of marrow stromal cultures [2] and Roberts et al [9] found that GM-CSF, like IL-3, binds to heparan sulphate.

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