Download Diagnostic Nuclear Medicine by C. Schiepers (auth.), Christiaan Schiepers MD, PhD (eds.) PDF

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By C. Schiepers (auth.), Christiaan Schiepers MD, PhD (eds.)

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1991; KRAUSZ et al. 1991; NEWTON 1992; THoMAs et al. 1992). Overall, these results demonstrate the high sensitivity in localizing seizure foei comparable to that of 18F_FDG PET (70%), but so me 24 G. Lucignani, J. J. Frost studies have shown a lower sensitivity, stimulating with 18p-PDG-PET imaging, SPECT perfusion imaging is more sensitive than MRI (CORDES et al. 1990). the use of ictal SPECT scanning. Due to the longer half-life of SPECT blood flow ra- The presence of interictal hypoperfusion is similarly diopharmaceuticals, the use of ictal and postictal more eommon in patients with T2-weighted MRI abscanning in patients with epilepsy has been explored normalities, as compared with patients with normal in recent years (Magistretti and UREN 1983; LEE et al.

Epilepsia 39:753-766 Bartenstein P, Ludolph A, Schober 0, Lottes G, Scheidhauer K, Seiuk J, Beer H-F (1991) Benzodiazepine reeeptors and cerebral blood flow in partial epilepsy. Eur J Nucl Med 18:111-118 Baumgartner C, Serles W, Leutmezer F, Pataraia E, Aull S, Czech T, Pietrzyk U, Relie A, Podreka I (1998) Preictal SPECT in temporal lobe epilepsy: regional cerebral blood flow is increased prior to eleetroencephalography-seizure onset. J Nucl Med 39:978-982 Beer HF, Bläuenstein PA, Hasler PH, Delaloye B, Riccabona G, Bangerl I, Hunkeler W, Bonetti EP, Pieri L, Richards JG, Schubiger PA (1990) In vitro and in vivo evaluation of iodine-123-Ro16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors.

The discovery that 201Tl accumulates in neoplastic tissue was serendipitous because it was observed in patients undergoing myocardial perfusion studies who also had tumors. The uptake of 2Ü1TI in brain tumors is related to blood flow, BBB integrity and malignant cell density, and is due to its similarities with potassium and thus on the Na+,K+,ATP-ase activity. 2Ü1Tl uptake is also related to tumor type: as the rate of uptake differs, 2ü1Tl cannot be used as a partial substitute for histologie characterization and grading.

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