By C.P. COYNE
Comparative Diagnostic Pharmacology: scientific and study functions in Living-System Models is the 1st evidence-based reference textual content committed completely to the topic of using pharmaceutical and biopharmaceutical brokers as diagnostic probes in medical drugs and investigative research.This precise and groundbreaking e-book is a flexible consultant for clinicians and researchers attracted to utilizing pharmacologic brokers to:
- Diagnose illness
- Assess physiological strategies
- Identify the appropriateness of a healing agent
- Determine acceptable dosing for healing use.
Extensively referenced and arranged through significant physique platforms, person issues are indexed in an evidence-based layout in keeping with particular affliction tactics or physiological strategies of curiosity. each one access additionally comprises info at the mechanism of motion, management, and diagnostic interpretation.
Descriptions were supplied for the applying of diagnostic prescribed drugs to evaluate a large spectrum of ailments and physiological techniques suitable to the fields of veterinary and human drugs. Comparative Diagnostic Pharmacology comes in handy now not in basic terms for pharmaceutical-oriented study investigations, however it also will turn out priceless for the tracking and overview of physiological responses and illness tactics in animal models.Content:
Chapter 1 Cardiovascular procedure (pages 5–60):
Chapter 2 important apprehensive method (pages 61–127):
Chapter three Endocrine approach (pages 129–177):
Chapter four Gastrointestinal procedure (pages 179–220):
Chapter five Hematopoietic procedure (pages 221–266):
Chapter 6 Hepatic process (pages 267–335):
Chapter 7 Integumentary process (pages 337–339):
Chapter eight Musculoskeletal method (pages 341–349):
Chapter nine Reproductive procedure (pages 351–354):
Chapter 10 Renal and Urinary platforms (pages 355–373):
Chapter eleven breathing process (pages 375–403):
Chapter 12 Cancer/Neoplastic disorder (pages 407–424):
Chapter thirteen Genetics and Nucleic Acids (pages 425–438):
Chapter 14 irritation, an infection, and Sepsis (pages 439–453):
Chapter 15 Metabolism, Electrolytes, and Hypoxia (pages 455–470):
Chapter sixteen Fluorescent and Pigment Dye Reagents (pages 473–516):
Chapter 17 Magnetic Resonance Imaging (MRI) (pages 517–567):
Chapter 18 Nuclear Planar Scintigraphy (pages 569–675):
Chapter 19 Positron Emission Tomography (PET) and unmarried Photon Emission Computed Tomography (SPECT) (pages 677–729):
Chapter 20 Radiographic Image?Enhancing brokers (pages 731–764):
Chapter 21 Ultrasonography (pages 765–808):
Chapter 22 organic and artificial supply Modalities (pages 811–905):
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Additional info for Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models
Circulation. 2003 Aug 26; 108 (8), pp. 1009–14. Epub 2003 Aug 11. 01CH_Coyne_BW_277044 10/7/05 12:01 PM Page 21 CHAPTER 1 CARDIAC DISEASE AND PHYSIOLOGY ANGINA: CARDIAC-ASSOCIATED THORACIC PAIN Angina Pectoris/Atherosclerosis: Coronary Artery/ Hydroxyapatite Deposition/Musculoskeletal: Osteoblastic Activity/Neoplastic Disease: Osteosarcoma Near-Infrared Light Emitting Probes/Fluorescent Bisphosphonate Derivatives/[Near-Infrared] Background Information: In vertebrates, the development and integrity of the skeleton requires hydroxyapatite (HA) deposition by osteoblasts.
Considerations: Prinzmetal’s variant angina is a form of angina caused by coronary-artery vasospasm (CAS) that is not associated with exertion. Nitrates, adrenergic-blocking agents, and calciumchannel blocking agents can be used in the treatment of PVA conditions. Nitroglycerin and isosorbide dinitrate effectively relieve CAS. However, long-term prospective studies on the use of these drugs for PVA are lacking in the literature. Studies on treating PVA with adrenergic-blocking agents have been equivocal, with some studies reporting improvement and some reporting worsening.
N ϭ 5/12 with vasospasm of the left anterior descending coronary artery; n ϭ 7/12 with spasm of a dominant right coronary artery). , n ϭ 2/12 cases). , n ϭ 7/11). , n ϭ 6 episodes per 4 cases). Provocative testing with the aid of cardiac catheterization procedures in concert with the cold pressor test or ergonovine maleate before and after nifedipine administration demonstrates that this agent is capable of blocking both ␣-adrenergic and ergonovineinduced vasospasms. Nifedipine may have a significant role in the diagnosis and therapy of angina caused by coronary spasm.