By Susan O'Brien, John G. Gribben
Written through authors from the world’s such a lot famous melanoma facilities, power Lymphocytic Leukemia provides a accomplished, up to date photo of CLL and the way to higher deal with sufferers inflicted with the sickness. New info on advancements within the molecular pathogenesis of this ailment affects how physicians technique and deal with sufferers with CLL. some of the predisposing elements for the disorder are addressed besides present and destiny therapy modalities and urged criteria of care. Key good points comprise: advent through Kanti Rai, MD who built the Rai category and Staging process utilized in CLL analysis CLL in courting to gene expression profiling and molecular abnormalities familial clustering and gene predisposition detailed treatment trials medical sufferer administration established upon degree and development of sickness
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Extra resources for Chronic Lymphocytic Leukemia
Weller S, Braun MC, Tan BK, et al. Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004; 104:3647–3654. 130. Kruetzmann S, Rosado MM, Weber H, et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 2003; 197:939–945. 131. Rolink AG, Andersson J, Melchers F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.
Since there were many questions remaining about CLL physiology and pathophysiology, this disease was an especially intriguing target for global gene expression profiling (GEP) analysis. 3d] [11/9/08/10:15:43] [19–34] 20 Klein approaches, helped gain new insights into phenotype, cell derivation, and pathogenesis of CLL. This chapter summarizes what we have learned so far about CLL from GEP analyses and discusses the surprising observations that emerged from the studies demonstrating that all CLL show a homogeneous expression profile, then explores the identity of the subtler CLL subtypes as well as the relation of the tumor cells to a putative normal counterpart, and attempts to place CLL in the framework of the various B-cell malignancies.
113. Dono M, Zupo S, Leanza N, et al. Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents. J Immunol 2000; 164:5596–5604. 114. Martin F, Kearney J. Marginal-zone B cells. Nat Rev Immunol 2002; 2:323–335. 115. Chen X, Martin F, Forbush KA, et al. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int Immunol 1997; 9:27–41. 116. Martin F, Oliver AM, Kearney JF. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.