By James S. Malpas MD DPhil FRCP FRCR FRCPCH, Daniel E. Bergsagel CM MD DPhil, Robert A. Kyle MD, Kenneth C. Anderson MD
Bone marrow-based malignancy is turning into extra common. There have additionally been significant advances within the prognosis, pathogenesis, and therapy of this universal tumor sort. In Biology and administration of a number of Myeloma, professional physicians and medical researchers summarize and clarify the new advances within the biology and remedy of this universal B-cell tumor. at the organic part, the authors overview the numerous very important, clinically correct discoveries which were made within the previous few years. They express the features of the malignant phone and describe the numerous roles performed by means of oncogenic adjustments, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic components also are analyzed. at the medical facet, the authors offer a complete evaluate of traditional remedy regimens, in addition to a dialogue of more recent experimental techniques concerning immunologic concentrating on, inhibitors of drug resistance, and antitumor brokers. The function of high-dose remedy is usually mentioned, besides the therapy of such issues as renal sickness, anemia, and bone sickness.
finished and authoritative, Biology and administration of a number of Myeloma deals either clinicians and researchers a completely up to date figuring out of the hot biology that may be at once utilized not just to destiny laboratory experiences, but additionally to the optimum remedy of myeloma sufferers today.
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Additional resources for Biology and Management of Multiple Myeloma
Asbestos The correlations between asbestos exposure and MM are particularly interesting, (4,5) with five out of nine published studies providing evidence of a significantly increased risk. Again, much of the data suggests that co-exposures may account for variations among analyses. 5. Benzene and Other Petrochemicals The correlation of benzene exposure with the incidence of myeloma in petroleum refining industries has led to particularly controversial data and conclusions (43 ). In several reports, investigators concluded that there is a correlation between benzene exposure and the risk for myeloma.
How can one assess an individual with a complex family and exposure history? Consider, for example, a patient who experienced all of the following prior to the onset of MM: a well-documented family history of hematologic cancer; lived in a farming community where pesticide spraying was common; regular use of black hair dye; infectious mononucleosis as child and hepatitis C as an adult; experienced a broken leg in a skiing accident that required the insertion of a pin; psychological stress when a child died tragically in an automobile accident.
REFERENCES I. Warburton P, Josua DE, Gibson J, Brown RD. CDIO-(Calla)-positive lymphocytes in 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. myeloma: evidence that they are a malignant precursor population and are of germinal centre origin. Leuk Lymphoma 1989; 1:11-12. Harris CC, Hollstein M. Clinical implications ofthe p53 tumor-suppressor gene. N Engl J Med 1992; 329:1318-1326. Potter M. The developmental history of neoplastic plasma cell in mice. Sem Haematol 1973; 10:19-31. Herrington LJ, Weiss NS, Olshan AD: Multiple myeloma.