Download Basic Sciences of Nuclear Medicine by G. S. Pant (auth.), Magdy M. Khalil (eds.) PDF

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By G. S. Pant (auth.), Magdy M. Khalil (eds.)

Nuclear drugs has develop into an ever-changing and increasing diagnostic and healing clinical career. The daily options noticeable within the box are, in nice half, as a result integration of many clinical bases with complicated technologic advances. the purpose of this reference booklet, easy Sciences of Nuclear drugs, is to supply the reader with a accomplished and certain dialogue of the clinical bases of nuclear drugs, overlaying the various subject matters and ideas that underlie a number of the investigations and systems played within the box. subject matters comprise radiation and nuclear physics, Tc-99m chemistry, single-photon radiopharmaceuticals and puppy chemistry, radiobiology and radiation dosimetry, photograph processing, snapshot reconstruction, quantitative SPECT imaging, quantitative cardiac SPECT, small animal imaging (including multimodality hybrid imaging, e.g., PET/CT, SPECT/CT, and PET/MRI), compartmental modeling, and tracer kinetics.

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Protein synthesis and peptide formation involve a slow kinetic process; thus, single-photon emitters provide an opportunity to study the underlying functional disorders while the tracer still is able to emit a signal [1]. Suitable radionuclide emission: Radiopharmaceuticals emitting g-radiation by electron capture or isomeric transition (energy between 30 and 300 keV) are commonly used in nuclear medicine diagnostic procedures. For therapeutic purposes, a-, b-, and Auger electron emitters are used because of their high linear energy transfer, which leads to maximum exposure and damage of the target cells.

10 Samarium-153 . . . . . . . . . . . . . . . . 11 111In- and 90Y-Ibritumomab Tiuxetan (Zevalin) . . . . . . . . . . . . . . 12 90Y-Labeled Microspheres . . . . . . . . . . 13 Lutetium-177 Compounds . . . . . . . . . . 37 References . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction A radiopharmaceutical is a radioactive compound that has two components, a radionuclide and a pharmaceutical; it is used for the diagnosis and treatment of human diseases.

7 Phosphorus-32 . . . . . . . . . . . . . . . . 8 Strontium-89 . . . . . . . . . . . . . . . . . 9 Rhenium-186 . . . . . . . . . . . . . . . . 10 Samarium-153 . . . . . . . . . . . . . . . . 11 111In- and 90Y-Ibritumomab Tiuxetan (Zevalin) . . . . . . . . . . . . . . 12 90Y-Labeled Microspheres . . . . . . . . . . 13 Lutetium-177 Compounds . . . . . . . . . . 37 References . . . . . . . . . . .

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