By Wojciech Gorczyca
This wide reference overlaying neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and mostly affected extranodal organs, with detailed emphasis at the differential prognosis. It discusses simple scientific, prognostic, morphologic and phenotypic facts, with a variety of tables summarizing the phenotypic profiles of the most typical hematologic tumors. a huge characteristic of this e-book is an method of hematologic tumors in line with the WHO type, with proper examples and emphasis at the most valuable morphologic and immunophenotypic positive aspects utilized in diagnosis.It could be a useful reference for all working towards hematologists, oncologists and pathologists.
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Additional resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
The lymphoid lineage also matures from stem cell to mature lymphocyte. A lymphocyte will become either a B-cell or a T-cell. T-cells are further subdivided into helper/inducer cells, suppressor/cytotoxic cells and NK-cells. T-cells regulate the B-cells, as well as kill infected cells in the body. The B-cells are programmed at birth to react against a specific glycoprotein sequence, or antigen. Each B-cell has a surface immunoglobulin (antibody) which contains a specific kappa or lambda light-chain configuration.
Flow cytometry immunophenotyping shows no loss of pan-T antigen expression (D–G). Lack of aberrant expression of pan-T antigens does no exclude malignancy. g. CD33 or CD117. 9 presents a comparison between the mature and precursor T-cell neoplasms. TALL/LBL more often shows dimmer expression of CD45, lack of CD2 and CD3 (surface), dual positive or dual negative CD4/CD8 expression, lack of TCR, and expression of CD10 and CD117 when compared to mature tumors20,22. 19 Flow cytometry immunophenotyping—CD4:CD8 ratio.
A lymphocyte will become either a B-cell or a T-cell. T-cells are further subdivided into helper/inducer cells, suppressor/cytotoxic cells and NK-cells. T-cells regulate the B-cells, as well as kill infected cells in the body. The B-cells are programmed at birth to react against a specific glycoprotein sequence, or antigen. Each B-cell has a surface immunoglobulin (antibody) which contains a specific kappa or lambda light-chain configuration. If the B-cell encounters its antigen match, the B-cell will undergo clonal expansion, making millions of copies of itself and differentiating into special types of Bcells eventually transforming into a plasma cell.