By Drew Provan
This moment variation of the ABC of scientific Haematology is a entire and functional consultant to this broad ranging speciality, overlaying the haematological facets of such components as pathology, molecular technological know-how, melanoma, and common drugs. this can be a brief quantity inclusive of chapters on all components of haematology written by way of those who care for those illnesses every day. The e-book offers descriptions of those illnesses and describes the pathways excited about analysis and remedy. complete color is used all through this seriously illustrated ebook, utilizing medical fabric and textual content bins to emphasize key issues. now we have additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require huge past wisdom.
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Additional info for ABC of Clinical Haematology (ABC Series)
Diagnosis The diagnosis of CML in the chronic phase can be made from a study of the peripheral blood film (Fig. 3). Marrow examination shows increased cellularity. The distribution of immature leucocytes resembles that seen in the blood film. Red cell production is relatively reduced. g. 4 Peripheral blood film from a patient with chronic myeloid leukaemia showing many mature granulocytes, including two basophils (arrow); a blast cell is prominent (double arrow). 4 Survival from CML • Raised white blood cell count (30–300 × 109/L).
3 Giant granular platelets in peripheral blood film as seen in Bernard-Soulier syndrome or May Hegglin anomaly. 4 Site of abnormality in congenital platelet disorders. Other conditions There are also a variety of further specific surface membrane defects and internal enzyme abnormalities, which, although difficult to define, can cause troublesome chronic bleeding problems (Fig. 5). Acquired abnormalities Decreased production of platelets Decreased platelet production caused by suppression or failure of the bone marrow is the commonest cause of thrombocytopenia.
Particularly important sources of infection in neutropenic patients include bacterial and fungal pneumonias, infections associated with indwelling central lines and infections of the sinuses and perineum. Early institution of broad spectrum antibiotics after appropriate investigations (blood cultures, chest X-ray and swabs of potentially infected sites) is vital. If patients are hypotensive, aggressive treatment of possible septic shock including aggressive fluid resuscitation and, if necessary, transfer to the intensive care unit are critical.