Download A Guide to Hematology in Dogs and Cats by A H Rebar; et al PDF

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By A H Rebar; et al

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Extra resources for A Guide to Hematology in Dogs and Cats

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As reticulocyte counts elevate above 200,000/µl, hemolysis should be suspected. 44 TNM GuideToHema:03058 TNM text_cp 6/28/07 3:49 PM Page 45 4 E RY T H R O C Y T E S Regenerative Anemias: Hemolytic Disease Hemolytic anemia occurs when the circulating red cell lifespan is reduced due to increased rates of RBC distruction. ® Hemolysis is the result either of a defect in the red cells (inherent or acquired) or a defect in the microvasculature through which the red cells circulate. Hemolysis can occur intravascularly (while the red cells are circulating) or extravascularly.

Macrocytes – large red cells ® Microcytes – small red cells Polychromasia – increased numbers of polychromatophils on the blood film. Hypochromasia – decreased hemoglobin concentration. Hypochromic red cells have enlarged areas of central pallor (Figure 4-10). Figure 4-9 Canine blood. Marked anisocytosis and poikilocytosis are present due to macrocytic cells, spherocytes, schistocytes, acanthocytes and microcytes (100x). See subsequent figures for indentification of specific poikilocytes. Figure 4-10 Canine blood.

Figure 4-7 Feline blood. Normal erythrocyte morphology. Feline RBCs are smaller than dog erythrocytes, exhibit a slight amount of crenation, and have a minimal area of central pallor (100x). Figure 4-8 Feline blood. Regenerative anemia. Immature RBCs are visible as larger erythrocytes that have bluegrey cytoplasm. These cells are termed macrocytic polychromatophilic erythrocytes. Two NRBCs (arrows) are noted and are smaller than a lymphocyte (100x). 34 TNM GuideToHema:03058 TNM text_cp 6/28/07 3:49 PM Page 35 4 E RY T H R O C Y T E S Morphology in Disease Anisocytosis – variation in red cell size (Figure 4-9).

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